The record
| Class | neuroprotective |
|---|---|
| Also known as | Cibinetide, pHBSP (pyroglutamate Helix B Surface Peptide) |
| Chain length | - |
| Molecular weight | 1,257.3 Da |
| Half-life | ~2 minutes (IV); ~20 minutes (SC) |
| Route | SC (preferred) or IV |
| Studied for | Sarcoidosis-associated small fiber neuropathy (Phase II); Diabetic neuropathy (Phase II); Neuropathic pain; Chronic inflammatory conditions |
| Research use | Innate repair receptor signaling; Neuroprotection models; Small fiber nerve regeneration |
| What has been shown | Reduces neuropathic pain in sarcoidosis (significant SFNSL improvement); Increases corneal nerve fiber density; Improves physical functioning and quality of life; Promotes small nerve fiber regeneration |
| How it works | Synthetic 11-amino acid peptide derived from the helix-B domain of erythropoietin (EPO). Selectively activates the innate repair receptor (IRR), a heteromer of EPO receptor and beta-common receptor (CD131). Triggers anti-inflammatory responses and promotes tissue repair including neuroprotection WITHOUT stimulating erythropoiesis (red blood cell production). |
| Patent status | proprietary (Araim Pharmaceuticals) |
| Regulatory status | Phase II/III clinical trials (not approved) |
Blank = not established in the record. Nothing is estimated to fill a gap.
Where it is matched
- Cartilage / Joint Comfort Environment (affection, 44%)
- Nerve Support / Neuro-repair Environment (affection, 83%)
- GI Inflammation Modulation (affection, 36%)
- Neuroprotection Signaling (affection, 59%)
- Inflammation Modulation (affection, 52%)
- ADHD (illness, 30%)
- Alzheimer's disease (illness, 45%)
- Bone pain from metastases (illness, 30%)
- Cancer immunotherapy adjuvant (illness, 30%)
- Chronic inflammatory conditions (illness, 100%)
- COVID-19 (illness, 30%)
- Diabetic neuropathy (illness, 100%)
- Hepatitis B/C treatment (illness, 30%)
- Hypercalcemia (illness, 30%)
- Neuropathic pain (illness, 100%)
- Paget's disease of bone (illness, 30%)
- Sarcoidosis-associated small fiber neuropathy (illness, 100%)
- Sepsis treatment (illness, 30%)
- Stroke recovery (illness, 38%)
- Traumatic brain injury (illness, 38%)
- Vaccine adjuvant (illness, 30%)
- Vascular dementia (illness, 45%)
- Pain (symptom, 100%)
- Low mood (symptom, 33%)
- Memory lapses (symptom, 50%)
- Frequent infections (symptom, 50%)