The record
| Class | reproductive |
|---|---|
| Also known as | Metastin, KP-10, KISS1 |
| Chain length | - |
| Molecular weight | 1,302.5 Da |
| Half-life | ≈4 minutes plasma t½ (reported: 3.8 ± 0.3 min in men; 4.1 ± 0.4 min in women). |
| Route | - |
| Studied for | Hypogonadotropic hypogonadism; Hypothalamic amenorrhea; IVF oocyte maturation trigger; PCOS treatment (investigational) |
| Research use | Reproductive axis studies; Puberty onset research; GPR54 receptor signaling |
| What has been shown | Stimulates LH and FSH release; Triggers oocyte maturation in IVF |
| How it works | Binds to GPR54/KISS1R receptor in hypothalamus, stimulating pulsatile release of gonadotropin-releasing hormone (GnRH), which triggers LH and FSH secretion from anterior pituitary. Acts as master regulator of hypothalamic-pituitary-gonadal axis. |
| Patent status | proprietary (Ever Neuro Pharma) |
| Regulatory status | approved in 45+ countries (not USA/UK) |
Blank = not established in the record. Nothing is estimated to fill a gap.
Where it is matched
- HPG Axis Signaling Support (affection, 81%)
- Hypogonadotropic hypogonadism (illness, 100%)
- Hypothalamic amenorrhea (illness, 100%)
- IVF oocyte maturation trigger (illness, 100%)
- PCOS treatment (illness, 100%)
- Pulsatile therapy for hypogonadotropic hypogonadism (illness, 60%)
- Low libido (symptom, 50%)