The record
| Class | antioxidant |
|---|---|
| Also known as | GSH, Glutathione, Reduced glutathione, L-gamma-glutamyl-L-cysteinyl-glycine |
| Chain length | - |
| Molecular weight | 307.32 Da |
| Half-life | Minutes to hours (tissue-dependent) |
| Route | IV, IM, oral (poor bioavailability) |
| Studied for | Antioxidant supplementation; Detoxification support; Skin lightening (IV); Acetaminophen toxicity (as NAC precursor) |
| Research use | Redox biology studies; Oxidative stress research; Thiol chemistry |
| What has been shown | Cellular antioxidant protection; Protein thiol maintenance; Xenobiotic conjugation |
| How it works | Master intracellular antioxidant. Tripeptide containing cysteine with free thiol group that serves as reducing equivalent. Detoxifies reactive oxygen species, maintains protein thiol status, conjugates xenobiotics via glutathione S-transferases. Regenerated from GSSG by glutathione reductase using NADPH. |
| Patent status | natural compound |
| Regulatory status | Dietary supplement, pharmaceutical ingredient |
Blank = not established in the record. Nothing is estimated to fill a gap.
Where it is matched
- Oxidative Stress Resilience (affection, 80%)
- Acetaminophen toxicity (illness, 100%)
- Age-related macular degeneration (illness, 40%)
- Antioxidant supplementation (illness, 100%)
- Barth syndrome (illness, 40%)
- Detoxification support (illness, 100%)
- Erythropoietic protoporphyria - FDA approved (illness, 30%)
- Heart failure (illness, 40%)
- Mitochondrial myopathies (illness, 40%)
- Polymorphous light eruption (illness, 30%)
- Skin lightening (illness, 100%)
- Solar urticaria (illness, 30%)
- Vitiligo (illness, 30%)
- Fatigue or low energy (symptom, 33%)