The record
| Class | antimicrobial |
|---|---|
| Also known as | CAP-18 (precursor), hCAP-18, Human Cathelicidin Antimicrobial Peptide, CAMP |
| Chain length | - |
| Molecular weight | 4,493.3 Da |
| Half-life | Short (minutes to hours) - rapidly degraded by proteases |
| Route | SC, topical, or sublingual |
| Studied for | Antimicrobial applications (broad-spectrum), Wound healing, Anti-biofilm treatment, Sepsis/endotoxemia protection, Immunomodulation |
| Research use | Antimicrobial peptide research, Innate immunity studies, Wound healing models, Biofilm disruption, Cancer research |
| What has been shown | Broad-spectrum antimicrobial activity (Gram+, Gram-, fungi, some viruses); LPS neutralization and endotoxin protection; Enhanced wound healing and angiogenesis; Biofilm disruption |
| How it works | LL-37 is the only human cathelicidin antimicrobial peptide, a 37-amino acid cationic amphipathic α-helical peptide. It disrupts bacterial cell membranes by forming oligomeric channels, neutralizes lipopolysaccharide (LPS) endotoxin, and modulates immune responses. Residues 13-34 form the amphipathic helix responsible for membrane insertion. |
| Patent status | various derivative patents |
| Regulatory status | research; no FDA approval for injectable use |
Blank = not established in the record. Nothing is estimated to fill a gap.
Where it is matched
- Joint / Tendon Healing (affection, 33%)
- Wound Healing / Tissue Repair (affection, 39%)
- GI Inflammation Modulation (affection, 62%)
- Inflammation Modulation (affection, 67%)
- Anti-biofilm treatment (illness, 100%)
- Antimicrobial applications (illness, 100%)
- Cancer immunotherapy adjuvant (illness, 60%)
- Cardiac repair (illness, 45%)
- Corneal injuries/dry eye (illness, 45%)
- COVID-19 (illness, 60%)
- Hepatitis B/C treatment (illness, 60%)
- Immunomodulation (illness, 100%)
- Neurotrophic keratopathy (illness, 45%)
- Sepsis treatment (illness, 60%)
- Sepsis/endotoxemia protection (illness, 100%)
- Vaccine adjuvant (illness, 60%)
- Wound healing (illness, 100%)
- Pain (symptom, 50%)
- Slow healing of an injury (symptom, 50%)
- Frequent infections (symptom, 100%)
- Swelling or inflammation (symptom, 50%)