The record
| Class | regenerative |
|---|---|
| Also known as | Tβ4, TB4, TB-4 |
| Chain length | - |
| Molecular weight | 4,963.51 Da |
| Half-life | Dose-dependent (increases with dose) |
| Route | SC, IV, topical |
| Studied for | Wound healing; Corneal injuries/dry eye; Cardiac repair (investigational); Neurotrophic keratopathy |
| Research use | Tissue regeneration; Cardiac ischemia models; Stroke recovery |
| What has been shown | Accelerates wound healing; Improves dry eye symptoms; Promotes angiogenesis; Reduces inflammation and scarring |
| How it works | 43-amino acid peptide that sequesters G-actin monomers, regulating actin polymerization and cytoskeletal dynamics. Promotes cell migration, angiogenesis, and stem/progenitor cell differentiation. Reduces inflammation, apoptosis, and scar formation by decreasing myofibroblasts. Contains LKKTET motif (actin-binding) and N-terminal SDKP sequence (anti-inflammatory). Released by platelets and macropha |
| Patent status | various patents |
| Regulatory status | investigational |
Blank = not established in the record. Nothing is estimated to fill a gap.
Where it is matched
- Joint / Tendon Healing (affection, 47%)
- Muscle Recovery (affection, 51%)
- Wound Healing / Tissue Repair (affection, 39%)
- GI Inflammation Modulation (affection, 36%)
- Inflammation Modulation (affection, 38%)
- Bone Health / Remodeling Support (affection, 31%)
- Anti-fibrotic Signaling Environment (affection, 48%)
- Anti-biofilm treatment (illness, 45%)
- Antimicrobial applications (illness, 45%)
- Cancer immunotherapy adjuvant (illness, 30%)
- Cardiac repair (illness, 100%)
- Corneal injuries/dry eye (illness, 100%)
- COVID-19 (illness, 30%)
- Hepatitis B/C treatment (illness, 30%)
- Immunomodulation (illness, 45%)
- Neurotrophic keratopathy (illness, 100%)
- Sepsis treatment (illness, 30%)
- Sepsis/endotoxemia protection (illness, 45%)
- Vaccine adjuvant (illness, 30%)
- Wound healing (illness, 100%)
- Pain (symptom, 50%)
- Slow healing of an injury (symptom, 75%)
- Muscle loss or weakness (symptom, 33%)
- Frequent infections (symptom, 50%)