The record
| Class | vasodilator |
|---|---|
| Also known as | Vasoactive Intestinal Peptide, Vasoactive Intestinal Polypeptide, PHM-27 related |
| Chain length | - |
| Molecular weight | 3,326 Da |
| Half-life | 1-2 minutes |
| Route | IV, inhaled, intranasal |
| Studied for | Pulmonary hypertension (investigational); COPD/asthma; Inflammatory bowel disease; Erectile dysfunction |
| Research use | Circadian rhythm studies; Vasodilation research; Immunomodulation |
| What has been shown | Potent pulmonary vasodilation; Bronchodilation; Anti-inflammatory effects; Promotes vaginal lubrication |
| How it works | 28-amino acid neuropeptide that binds to VPAC1 and VPAC2 G-protein coupled receptors, activating adenylyl cyclase and increasing cAMP. Causes potent vasodilation, smooth muscle relaxation, stimulates water/electrolyte secretion, inhibits gastric acid secretion. Key role in circadian rhythm (SCN), immune modulation, and neurotransmission. Anti-inflammatory properties. |
| Patent status | expired (natural peptide) |
| Regulatory status | research |
Blank = not established in the record. Nothing is estimated to fill a gap.
Where it is matched
- Muscle Recovery (affection, 43%)
- Cartilage / Joint Comfort Environment (affection, 44%)
- GI Inflammation Modulation (affection, 36%)
- Inflammation Modulation (affection, 38%)
- Vascular / Endothelial Support (affection, 38%)
- Acromegaly (illness, 60%)
- AIDS-related diarrhea (illness, 60%)
- Cancer immunotherapy adjuvant (illness, 30%)
- COPD/asthma (illness, 100%)
- COVID-19 (illness, 30%)
- Erectile dysfunction (illness, 100%)
- Esophageal variceal bleeding (illness, 60%)
- FDA-approved for hypoactive sexual desire disorder in premenopausal women (illness, 30%)
- Hepatitis B/C treatment (illness, 30%)
- Inflammatory bowel disease (illness, 100%)
- Neuroendocrine tumors (illness, 60%)
- Pulmonary hypertension (illness, 100%)
- Sepsis treatment (illness, 30%)
- Vaccine adjuvant (illness, 30%)
- Pain (symptom, 50%)
- Poor circulation or cold extremities (symptom, 50%)
- Frequent infections (symptom, 50%)